Application shows error context out of request in flask in ibmqradar

I want to know the best practices used by the QRadar developers community to run the process in background. Like QRadar provides the SDK for building the apps which is in Python and used Flask Web application framework now I want to create an app that poll the data from the server and update the QRadar Reference sets. I come to know there are 3 options. Threads(which throws error ) flask-celery Crontab